Genomes - the basics
Table of Contents
Genomes
What is a genome?
DNA
What are genomes made of?
Comparing genomes
How much DNA?
DNA's code
What is DNA's alphabet?
Making proteins
What are proteins made of?
An Example (with codon wheel)
Genes and 'junk'
What does the rest of the DNA do?
Variation
Am I unique?
How can mutations cause disease?
Where to next...?
Genomes - in detail
Table of Contents
In our cells
From microscopes to molecules
DNA: stuff of life
The chemical
DNA structure
From structure to function
Genes: DNA's instructions
What are genes?
Transcription: copying the code
Translating the genetic code
Assembling the protein chain
Genomes: not just genes
Making molecules
Regulating protein production
Many genomes: variation
Am I unique?
Mutations: large and small
Where to next...?
The Human Genome Project
Table of Contents
Overview
An immense enterprise
History
Background to big biology
Starting small
Approaches
Approaches to sequencing
Sequencing
Making maps
Making libraries
Sanger method
The sequencing reaction
Detecting the DNA
Publication
A draft
Finishing the sequence
FAQ
Sequencing centre
Welcome
Sanger sequencing pipeline
Making maps
DNA libraries
Sequencing
Finishing
Accessing information
New sequencing technologies
Sequencing at speed
Genome Explorer
InsideDNA's Genome Explorer
Pharmacogenomics
Table of Contents
Background
Just what are pharmacogenomics and pharmacogenetics?
Human genetic variation
Adverse drug reactions because of genetics
Variation in responses to drug treatment
Scientific opportunities
Pharmacogenetics and cancer
From gene to biological 'marker' of disease
Medical use
Pharmacogenetics in action
Abacavir
: Pharmacogenetics in practice
Warfarin
: Pharmacogenetic potential
Medical challenges
Challenges to overcome
Biobanking and population genomics
Social & ethical issues
Personal genomics
Personal genetic information
Direct-to-consumer testing
UK National DNA database
Overview
How the NDNAD has evolved
What the data looks like
Using the database
Taking storing accessing samples
NDNAD benefits
Ethical issues
Further information
Personal genome sequencing
We're all different
Your genome and your health
Genomic disorders
Introduction
Structural variation
Genomic rearrangements
Array technologies
Birth of personal genomics
Primate evolution
Arrays in the clinic
Early embryos
From gene to treatment
Unraveling autism genetics
Evolution of Brain, Behaviour & Intelligence
Genes and genomes
Introduction
Genes and genomes
Is RNA the missing link?
All change
From DNA to RNA - and back again?
The neanderthal genome
A synapse through time
Flies and worms
Flies and worms
Worms flock together
Let sleeping flies lie
Birds: bright and beautiful
The song doesn't remain the same
Avian singsong
Birds: bright & beautiful
Building a brain
The early worm
Virtual paleoanthropology
More cells, more cells
Mapping the brain
Language & communication
Language and communication
FOXP2: a genetic window into speech
Talking with neanderthals
DNA and Proteins
Zoom in on your genome
Origami DNA
Sequence bracelets
Yummy gummy double helix
What's my name in DNA?
From DNA to protein
Function finders
Cell Snap
HGP and gene technology
How the human genome was sequenced
DNA libraries - making a BAC library
Subcloning
DNA sequencing
Sequencing at Speed
Cancer
KRAS
: Cancer mutation
Cancer: Rogue Cells
The role of Cancer genes
Pathogens
Horizontal Gene Transfer
Build a Bug
Balloon Bugs
Sneeze Zone
Handshake Hazard
Contamination Detectives
MRSA Animation
MRSA: Gene hunt
Malaria Challenge
Malaria Challenge
The Big Debate
Funding Decisions
Managing Malaria
Malaria: an introduction
Model Organisms
Spot the difference: Zebrafish
About us
Requirements
Navigation
Sitemap
Credits
Resources
Animations
Activities
Researchers
Glossary
Links
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Table of contents
DNA, Genes and Genomes - General
Genomes
What is a genome?
Where do genomes come from?
DNA
What are genomes made of? Why is DNA's shape important?
Comparing genomes
How much DNA?
How many chromosomes?
DNA's code
What is DNA's alphabet?
Making proteins
What are proteins made of? Three DNA letters, one amino acid?
An Example (with codon wheel)
Genes and 'junk'
What does the rest of the DNA do? Controls and repeats.
Variation
Am I unique?
Can genomes change?
How can mutations cause disease?
Inheriting mutations