Next-generation sequencing brought with it a fundamentally different approach to DNA sequencing, cutting the time and cost needed to sequence a genome.
The mouse is closely related to humans with a striking similarity to us in terms of anatomy, physiology and genetics. This makes the mouse an extremely useful model organism.
Personal genomics is an area of genomics focusing specifically on the sequencing and analysis of one person’s genome, and then giving them their genomic information.
Pharmacogenomics is a specific kind of genetic testing that offers key advantages for doctors trying to choose the best drugs for their patients.
How was DNA discovered to be the carrier of genetic information? Read on to find out...
Automatic DNA sequencing machines became commercially available in the late 1980s. They allowed scientists to carry out DNA sequencing more safely and efficiently.
By the mid-1990s, when the Human Genome Project was in full swing, scientists were sequencing DNA using capillary sequencers.
Although cholera is commonly thought to be a disease of the Victorian era, it is still a significant problem in many areas of the modern world. Genomics research is helping to bring us closer to understanding how we may eliminate it once and for all.
The 1950s and early 1960s saw a dazzling explosion in molecular biology. The structure of DNA had been uncovered and the mysteries of biology seemed eminently solvable. What would be the next big thing?
While many species of amphibians have been studied by scientists, the one that stands out in genetics is the African clawed frog, Xenopus laevis.
The Sanger sequencing method, developed in 1977, enabled scientists to read the genetic code for the first time. It is based on the natural process of DNA replication.
How was DNA first discovered and who discovered it? Read on to find out...
Resistance to antimalarial drugs is one of the biggest problems currently facing malaria control. Recent studies looking at the genome of the malaria parasite could help scientists understand how drug resistance has evolved – and develop the tools needed to keep it in check.
John Sulston and Bob Waterston led the way for the Human Genome Project after they successfully sequenced the genome of the nematode worm, Caenorhabditis elegans, the first animal to be sequenced.
In 1984, Alec Jeffreys developed the technique of DNA fingerprinting in his laboratory at the University of Leicester. These techniques have revolutionised the way that the police solve crimes.
With third generation sequencing, sequencing a genome has become a cheaper, faster and more sophisticated process.
The zebrafish (Danio rerio) has become a popular model organism only relatively recently. It is a tropical fish from the minnow family with a genetic structure surprisingly similar to ours.
Infectious diseases can spread quickly in a hospital environment, particularly if the pathogen that causes the disease is resistant to the drugs relied on to fight it. Genomics may be able to help track these resistant pathogens and nip them in the bud before they become widespread…
Some children with severe combined immunodeficiency (SCID), a genetic disorder characterised by a reduced number of immune cells, have been treated using gene therapy.
The discovery of the structure of DNA by James Watson and Francis Crick in 1953 is one of the most famous scientific discoveries of all time.
Yeast is one of the simplest eukaryotic organisms but many essential cellular processes are the same in yeast and humans. It is therefore an important organism to study to understand basic molecular processes in humans.
DNA sequencing is the process of working out the order of the bases, A, C, G and T, in a strand of DNA.
The Human Genome Project, which began officially in 1990, was the largest international collaboration ever undertaken in biology and involved thousands of scientists.
The announcement of the first draft of the human genome on 26 June 2000 was big news.
In 2003, two years ahead of schedule, scientists announced that the human genome had been sequenced with an accuracy of 99.99 per cent. It was described as ‘the end of the beginning’.
The Human Genome Project brought scientists together from across the globe. Worldwide collaboration and support was an essential part of the project’s success.
The entry of Celera Genomics into the human genome sequencing arena in 1998 galvanised the public effort, leading to a race to sequence the human genome.
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