Targeting Disease

Defeating the little dragon

Infectious diseases can spread quickly in a hospital environment, particularly if the pathogen that causes the disease is resistant to the drugs relied on to fight it. Genomics may be able to help track these resistant pathogens and nip them in the bud before they become widespread…

How is genomics being used to tackle neglected tropical diseases?

The Guinea worm is a water-transmitted parasite that develops over a year in its host before painfully emerging from the skin. It is hoped that it will soon become the first parasite to be eradicated but there are a few challenges to overcome first…

Neglected tropical diseases affect the poorest of the world’s populations but relatively little is known about their biology. Genomics is now providing insight into these diseases and enabling scientists to develop new strategies to prevent and treat these debilitating diseases.

What are helminths?

The ongoing battle against drug resistant malaria

Helminths are worm-like parasites that survive by feeding on a living host to gain nourishment and protection, sometimes resulting in illness of the host. There are a variety of different helminths from the very large to the microscopic.

How is pharmacogenomics being used?

Resistance to antimalarial drugs is one of the biggest problems currently facing malaria control. Recent studies looking at the genome of the malaria parasite could help scientists understand how drug resistance has evolved – and develop the tools needed to keep it in check.

In a small number of cases, doctors are able to use pharmacogenomics in their treatment of patients.

A weapon against malaria

Malaria: the master of disguise

Malaria parasites have a complex life cycle and high variability which has made the development of a vaccine a real challenge. Currently the most advanced vaccine candidate is RTS,S.

Sequencing the genome of the malaria parasite has revealed interesting clues as to how it is able to evade the human immune system for long enough to cause disease.

What is schistosomiasis?

What is African sleeping sickness?

Schistosomiasis is a tropical disease caused by a parasite. The parasite is transmitted through contact with fresh water contaminated with the parasite’s larvae.

How is malaria treated and prevented?

African trypanosomiasis is a parasitic disease transmitted by the tsetse fly. It gets its nickname ‘sleeping sickness’ because symptoms can include a disturbed sleep pattern.

Malaria is an entirely preventable and treatable disease if tackled early enough. However, there are growing problems with drug resistance that are posing a threat to the global fight against malaria.

What is malaria?

My career in genomics: antibiotic resistance

Spread by mosquitos, malaria is one of the most common infectious diseases and a global public health challenge.

My career in genomics: immune diseases

In this film Christine Boinett talks about her research looking at antibiotic resistance in bacteria. This is one of a series of films providing a unique insight into different careers in the field of genomics.

My career in genomics: cancer biology

In this film Gosia Trynka talks about her research looking at the effect of genetic changes on the immune system. This is one of a series of films providing a unique insight into different careers in the field of genomics.

BRAF: From Gene to Cancer Therapy (video)

In this film Niki Patel talks about her research looking at the genetics of cancer. This is one of a series of films providing a unique insight into different careers in the field of genomics.

Pharmacogenomics and cancer

This film tells the story of how DNA sequencing was used to identify that the gene BRAF is commonly mutated in malignant melanoma, and how this has led to the development of a targeted drug against the mutation.

Pharmacogenomics is a specific kind of genetic testing that offers key advantages for doctors trying to choose the best drugs for their patients.

Adverse drug reactions

An adverse drug reaction is when a medication given as instructed and at a normal dose has an unwanted or harmful effect on a patient.

What is gene therapy?