Humans have been breeding animals for millenia to bring out desirable characteristics. With the thoroughbred race horse there's lots of money at stake but with research mice it's the possibility of life-saving new treatments.
Although cholera is commonly thought to be a disease of the Victorian era, it is still a significant problem in many areas of the modern world. Genomics research is helping to bring us closer to understanding how we may eliminate it once and for all.
Infectious diseases can spread quickly in a hospital environment, particularly if the pathogen that causes the disease is resistant to the drugs relied on to fight it. Genomics may be able to help track these resistant pathogens and nip them in the bud before they become widespread…
In 1984, Alec Jeffreys developed the technique of DNA fingerprinting in his laboratory at the University of Leicester. These techniques have revolutionised the way that the police solve crimes.
The Guinea worm is a water-transmitted parasite that develops over a year in its host before painfully emerging from the skin. It is hoped that it will soon become the first parasite to be eradicated but there are a few challenges to overcome first…
Neglected tropical diseases affect the poorest of the world’s populations but relatively little is known about their biology. Genomics is now providing insight into these diseases and enabling scientists to develop new strategies to prevent and treat these debilitating diseases.
Resistance to antimalarial drugs is one of the biggest problems currently facing malaria control. Recent studies looking at the genome of the malaria parasite could help scientists understand how drug resistance has evolved – and develop the tools needed to keep it in check.
Sequencing the genome of the malaria parasite has revealed interesting clues as to how it is able to evade the human immune system for long enough to cause disease.
Malaria parasites have a complex life cycle and high variability which has made the development of a vaccine a real challenge. Currently the most advanced vaccine candidate is RTS,S.
How was DNA first discovered and who discovered it? Read on to find out...
In a small number of cases, doctors are able to use pharmacogenomics in their treatment of patients.
Have you ever wanted to know more about your genetic make-up? Direct-to-consumer testing is now making this possible through tests you can order online. But is there a more serious side to us having such easy access to all of the information in our genomes?
Allan Bradley was director of the Wellcome Trust Sanger Institute from 2000 to 2010. His appointment as director coincided with the completion of the draft human genome sequence by the Human Genome Project.
Genome-wide association studies have led to the discovery of hundreds of genes with a role in common diseases.
Robert H. Waterston is an American biologist well known for his work on sequencing the genome of the nematode worm C. elegans alongside John Sulston. He is also recognised for his part in sequencing the human, mouse and chimpanzee genomes.
The discovery of the structure of DNA by James Watson and Francis Crick in 1953 is one of the most famous scientific discoveries of all time.
How was DNA discovered to be the carrier of genetic information? Read on to find out...
The zebrafish (Danio rerio) has become a popular model organism only relatively recently. It is a tropical fish from the minnow family with a genetic structure surprisingly similar to ours.
The mouse is closely related to humans with a striking similarity to us in terms of anatomy, physiology and genetics. This makes the mouse an extremely useful model organism.
Professor Dame Janet Thornton was director of the European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), which shares the Wellcome Genome Campus with the Wellcome Trust Sanger Institute, from 2001 to 2015.
Yeast is one of the simplest eukaryotic organisms but many essential cellular processes are the same in yeast and humans. It is therefore an important organism to study to understand basic molecular processes in humans.
Rosalind Elsie Franklin was a British biophysicist and X-ray crystallographer whose fundamental research was critical to Watson and Crick’s discovery of the structure of DNA.
Maurice Wilkins shared the Nobel Prize with Francis Crick and James Watson in 1962 for their joint discovery of the structure of DNA. Naturally reticent, Wilkins didn’t initially stand forward to give his own account of the DNA story so few knew of his direct involvement in the project.
James Watson and his British colleague Francis Crick discovered the double helix structure of DNA. For this fundamental finding James, Francis and Maurice Wilkins were awarded the Nobel Prize for Physiology or Medicine in 1962.
The Sanger Institute takes its name from the double Nobel Prize winner and ‘father of genomics’, Frederick Sanger.
Francis Crick and his American colleague, James Watson, discovered the double helix structure of DNA. For this fundamental finding Francis, James and Maurice Wilkins were awarded the Nobel Prize for Physiology or Medicine in 1962.
Dr Francis Collins led the Human Genome Project from 1993. In his work, he was responsible for discovering the genes mutated in cystic fibrosis and Huntington’s disease. He is currently director of the US National Institutes of Health (NIH).
Professor Sir John Sulston was the founding director of the Sanger Centre (now the Wellcome Trust Sanger Institute) from 1992 until 2000 when the ‘working draft’ of the human genome sequence was completed.
While many species of amphibians have been studied by scientists, the one that stands out in genetics is the African clawed frog, Xenopus laevis.
Pharmacogenomics is a specific kind of genetic testing that offers key advantages for doctors trying to choose the best drugs for their patients.
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