Personal genomics is an area of genomics focusing specifically on the sequencing and analysis of one person’s genome, and then giving them their genomic information.
For much of nature, natural selection and ‘survival of the fittest’ still play a dominant role; only the strongest can survive in the wild. As little as a few hundred years ago, the same was true for humans, but what about now?
The origin of modern humans has probably been the most debated issue in evolutionary biology over the last few decades.
The human brain, in all its staggering complexity, is the product of millions of years of evolution.
Eric Lander is the founding director of the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard. He was one of the leaders of the Human Genome Project and his work has been key in developing tools to investigate disease.
Professor Sir Mike Stratton is the director of the Wellcome Trust Sanger Institute and co-leader of the Cancer Genome Project.
An adverse drug reaction is when a medication given as instructed and at a normal dose has an unwanted or harmful effect on a patient.
It has been over a decade since the Human Genome Project was finished, so what has been happening since and how is the completed human genome sequence being used?
In 2003, two years ahead of schedule, scientists announced that the human genome had been sequenced with an accuracy of 99.99 per cent. It was described as ‘the end of the beginning’.
The announcement of the first draft of the human genome on 26 June 2000 was big news.
The entry of Celera Genomics into the human genome sequencing arena in 1998 galvanised the public effort, leading to a race to sequence the human genome.
The Human Genome Project was a pioneer for encouraging open access to scientific research. In 1996, those involved agreed that all new information produced should be made freely available to all within 24 hours.
Some scientists involved in the Human Genome Project upset the collaborative nature by trying to patent sections of the DNA sequence for their own financial gain.
John Sulston and Bob Waterston led the way for the Human Genome Project after they successfully sequenced the genome of the nematode worm, Caenorhabditis elegans, the first animal to be sequenced.
The Human Genome Project brought scientists together from across the globe. Worldwide collaboration and support was an essential part of the project’s success.
It was a project of such a huge size that no one thought it would be possible at that time, but with the support of key scientists and considerable funding, the Human Genome Project began…
Genetic counsellors are health professionals who help people faced with the possibility of a genetic disease to make informed decisions about their futures.
Next-generation sequencing brought with it a fundamentally different approach to DNA sequencing, cutting the time and cost needed to sequence a genome.
With third generation sequencing, sequencing a genome has become a cheaper, faster and more sophisticated process.
Automatic DNA sequencing machines became commercially available in the late 1980s. They allowed scientists to carry out DNA sequencing more safely and efficiently.
The Sanger sequencing method, developed in 1977, enabled scientists to read the genetic code for the first time. It is based on the natural process of DNA replication.
Some children with severe combined immunodeficiency (SCID), a genetic disorder characterised by a reduced number of immune cells, have been treated using gene therapy.
DNA sequencing is the process of working out the order of the bases, A, C, G and T, in a strand of DNA.
The 1950s and early 1960s saw a dazzling explosion in molecular biology. The structure of DNA had been uncovered and the mysteries of biology seemed eminently solvable. What would be the next big thing?
The Human Genome Project, which began officially in 1990, was the largest international collaboration ever undertaken in biology and involved thousands of scientists.
By the mid-1990s, when the Human Genome Project was in full swing, scientists were sequencing DNA using capillary sequencers.
The fruit fly, also known as Drosophila melanogaster, has the longest history in genetics and research out of all the model organisms.
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